AST Journal Club

The general purpose of the AST Journal Club is to select articles from biomedical literature that report on cutting edge science and warrant attention by transplant professionals attempting to keep pace with important advances in transplant medicine.

Any member can submit an article for posting consideration. Only articles from the AST’s journal, the American Journal of Transplantation, will be provided in full. All other articles will have a link provided to the abstract.

To submit an article to the journal club, please send an email to info@a-s-t.org..

January 2010

Nuclear Factor-kB Modulates Regulatory T Cell Development by Directly Regulating Expression of Foxp3 Transcription Factor: http://www.cell.com/immunity/comments/S1074-7613(09)00500-7

Meixiao Long, Sung-Gyoo Park, Ian Strickland, Matthew S. Hayden, and Sankar Ghosh

Immunity 31, 921-931, December 18, 2009

May 2009

Cutting Edge: Regulatory T Cells Do Not Require Stimulation through their TCR to Suppress: http://www.jimmunol.org/cgi/content/abstract/182/9/5188

Andrea L. Szymczak-Workman, Creg J. Workman, and Dario A. A. Vignali

The Journal of Immunology, 2009, 182:5188-5192

April 2009

B Cells Suppress the Inflammatory Response in a Mouse Model of Primary Biliary Cirrhosis

Yuki Moritok, Weici Zhang, Koichi Tsuneyama, Katsunori Yoshida, Kanji Wakaboyashi, Guo-Xiang Yang, Christopher Bowlus, William M. Ridgway, Yoshiyuki Ueno, Aftab A. Ansari, Ross L. Coppel, Ian R. Mackay, Richard A. Flavell, M. Eric Gershwin, and Zhe-Xiong Lian

Gastroenterology 2009;136:1037-1047

Outcomes of Kidneys from Donors After Cardiac Death: Implications for Allocation and Preservation

J.E. Locke, D.L. Segev, D.S. Warren, F. Dominici, C.E. Simpkins and R.A. Montgomery

American Journal of Transplantation 2007; 7:1797-1807

Parental Donors in Live-Donor Kidney Transplantation Associated with Increased Rejection Rates and Reduced Glomerular Filtration Rates: http://journals.lww.com/transplantjournal/Abstract/2007/10270/Parental_Donors_in_Live_Donor_Kidney.9.aspx

Wai H. Lim, Sean H. Chang, P. Toby Coates, and Stephen P. McDonald

Transplantation 2007;84:972-980

Recurrence Risk After Organ Transplantation in Patients with a History of Hodgkin Disease or Non-Hodgkin Lymphoma: http://journals.lww.com/transplantjournal/Abstract/2004/10150/Recurrence_Risk_After_Organ_Transplantation_in.4.aspx

Jennifer Trofe, Joseph F. Buell, E. Steve Woodle, Thomas M. Beebe, Michael J. Hanaway, M. Roy First, Rita R. Alloway, and Thomas G. Gross

Transplantation 2004, 78:972-977

March 2009

Identifying Specific Causes of Kidney Allograft Loss

Z.M. El-Zoghby, M.D. Stegall, D.J. Lager, W.K. Kremers, H. Amer, J.M. Gloor and F.G. Cosio

American Journal of Transplantation 2009; 9:527-535

Formal Policies and Special Informed Consent Are Associated with Higher Provider Utilization of CDC High-Risk Donor Organs

L.M. Kucirka, R. Namuyinga, C. Hanrahan, R.A. Montgomery and D.L. Segev

American Journal of Transplantation 2009; 9:629-635

PDE5A Inhibitor Treatment of Persistent Pulmonary Hypertension After Mechanical Circulatory Support: http://circheartfailure.ahajournals.org/cgi/content/abstract/1/4/213

Ryna J. Tedford, MD; Anna R. Hemnes, MD; Stuart D. Russell, MD; Ilan S. Wittstein, MD; Mobusher Mahmud, MD; Ari L. Zaiman, MD; Stephen C. Mathai, MD, MHS; David R. Thiemann, MD; Paul M. Hassoun, MD; Reda E. Girgis, MD; Jonathan B. Orens, MD; Ashish S. Shah, MD; David Yuh, MD; John V. Conte, MD; Hunter C Champion, MD, PhD

Circ Heart Fail 2008;1;213-219

Effector memory T cell responses are associated with protection of rhesus monkeys from mucosal simian immunodeficiency virus challenge: http://www.nature.com/nm/journal/v15/n3/abs/nm.1935.html

Scott G. Hansen, Cassandra Vieville, Nathan Whizin, Lia Coyne-Johnson, Don C. Siess, Derek D. Drummond, Alfred W. Legasse, Michael K. Anthelm, Kelli Oswald, Charles M. Trubey, Michael Piatak Jr., Jeffrey D. Lifson, Jay A. Nelson, Michael A. Jarvis, and Louis J. Picker

2009 Nature Medicine

Selective delivery of B cell antigen to dendritic cells in vivo leads to deletion and tolerance of autoreactive CD8+ T cells in NOD mice: http://www.biomedexperts.com/Abstract.bme/18430797/Selective_delivery_of_beta_cell_antigen_to_dendritic_cells_in_vivo_leads_to_deletion_and_tolerance_of_autoreactive_CD8

Arunika Mukhopadhaya, Tadashi Hanafusa, Irene Jarchum, Yi-Guang Chen, Yoshiko Iwai, David V. Serreze, Ralph M. Steinman, Kristin V. Tarbell, and Teresa P. DiLorenzo

PNAS, April 29, 2008, vol. 105, no. 17;6374-6379

Purging metastases in lymphoid organs using a combination of antigen-nonspecific adoptive T cell therapy, oncolytic virotherapy and immunotherapy: http://www.nature.com/nm/journal/v14/n1/abs/nm1681.html

Jian Qiao, Timothy Kottke, Candice Willmon, Feorillo Galivo, Phonphimon Wongthida, Rosa Maria Diaz, Jill Thompson, Pamela Ryno, Glen N. Barber, John Chester, Peter Selby, Kevin Harrington, Alan Melcher and Richard G. Vile

2009 Nature Medicine

Dendritic Cell Antigen Presentation Drives Simultaneous Cytokine Production by Effector and Regulatory T Cells in Inflamed Skin: http://www.ncbi.nlm.nih.gov/pubmed/19200757?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

James B. McLachlan, Drew M. Catron, James J. Moon, and Marc K. Jenkins

Immunity 30, 277-288, February 20, 2009

A Nonsimultaneous, Extended, Altruistic-Donor Chain: http://content.nejm.org/cgi/content/short/360/11/1096

Michael A. Rees, MD, PhD, Jonathan E. Kopke, BS, Ronald P. Pelletier, MD, Dorry L. Segev, MD, Matthew E. Rutter, MD, Alfredo J. Fabrega, MD, Jeffrey Rogers, MD, Oleg G. Pankewycs, MD, Janet hiller, MSN, Alvin E. Roth, PhD, Tuomas Sandholm, PhD, M. Utku Unver, PhD, and Robert A. Montgomery, MD, DPhil

N ENGL J MED 360;11, March 12, 2009

February 2009

Invariant NKT cells reduce the immunosuppressive activity of influenza A virus–induced myeloid-derived suppressor cells in mice and humans: http://www.jci.org/articles/view/36264

Carmela De Santo, Mariolina Salio, S. Hajar Masri, Laurel Yong-Hwa Lee, Tao Dong, Anneliese O. Speak, Stefan Porubsky, Sarah Booth, Natacha Veerapen, Gurdyal S. Besra, Hermann-Josef Gröne, Frances M. Platt, Maria Zambon, and Vincenzo Cerundolo

J. Clin. Invest. doi:10.1172/JCI36264

Posttransplant HLA Alloreactivity in Stable Kidney Transplant Recipients—Incidences and Impact on Long-Term Allograft Outcomes

G. Bartela, H. Regeleb, M. Wahrmanna, N. Huttaryb, M. Exnerc, W. H. Horl and G. A. Bohmiga

American Journal of Transplantation 2008; 8: 2652–2660

Differential Roles of Direct and Indirect Allorecognition Pathways in the Rejection of Skin and Corneal Transplants: http://journals.lww.com/transplantjournal/Abstract/2009/01150/Differential_Roles_of_Direct_and_Indirect.4.aspx

Florence Boisgerault, Ying Liu, Nathalie Anosova, Reza Dana, and Gilles Benichou

Transplantation 2009; 87: 16–23

CardioWest (Jarvik) Total Artificial Heart: A Single-Center Experience With 42 Patient: http://ats.ctsnetjournals.org/cgi/content/full/87/1/124

Jean Christian Roussel, MD, Thomas Sénage, MD, Olivier Baron, MD, Christian Périgaud, MD, Oussama Habash, MD, Jean Christophe Rigal, MD,Michèle Treilhaud, MD, Jean Noel Trochu, MD, PhD, Philippe Despins, MD, and Daniel Duveau, MD

Ann Thorac Surg 2009;87:124 –30

Proteasome Inhibition Causes Apoptosis of Normal Human Plasma Cells Preventing Alloantibody Production

D. K. Perrya, J. M. Burnsa, H. S. Pollingera, B. P. Amiotd, J. M. Gloorb, G. J. Goresc and M. D. Stegall

American Journal of Transplantation 2009; 9: 201–209

Bortezomib Provides Effective Therapy for Antibody- and Cell-Mediated Acute Rejection: http://journals.lww.com/transplantjournal/pages/articleviewer.aspx?year=2008&issue=12270&article=00024&type=abstract

Matthew J. Everly, Jason J. Everly, Brian Susskind, Paul Brailey, Lois J. Arend, Rita R. Alloway, Prabir Roy-Chaudhury, Amit Govil, Gautham Mogilishetty, Adele H. Rike, Michael Cardi, George Wadih, Amit Tevar, and E. Steve Woodle

Transplantation 2008; 86: 1754–1761

Bone marrow stromal cells attenuate sepsis via prostaglandin E2–dependent reprogramming of host macrophages to increase their interleukin-10 production: http://www.nature.com/nm/journal/v15/n1/abs/nm.1905.html

Krisztian Nemeth, Asada Leelahavanichkul, Peter S T Yuen, Balazs Mayer, Alissa Parmelee, Kent Doi, Pamela G Robey, Kantima Leelahavanichkul, Beverly H Koller, Jared M Brown, Xuzhen Hu, Ivett Jelinek, Robert A Star, & Eva Mezey

Nature Medicine 2009; 15,1. doi:10.1038/nm.1905

Machine Perfusion or Cold Storage in Deceased-Donor Kidney Transplantation: http://content.nejm.org/cgi/content/short/360/1/7

Cyril Moers, M.D., Jacqueline M. Smits, M.D., Ph.D., Mark-Hugo J. Maathuis, M.D., Ph.D., Jugen Treckmann, M.D., Frank van Gelder, Bogdan P. Napieralski, Margitta van Kasterop-Kutz, Jaap J. Homan van der Heide, M.D., Ph.D., Jean-Paul Squifflet, M.D., Ph.D., Ernest van Heurn, M.D., Ph.D., Gunter R. Kirste, M.D., Ph.D., Axel Rahmel, M.D., Ph.D., Henri G.D. Leuvenink, Ph.D., Andreas Paul, M.D., Ph.D., Jacques Pirenne, M.D., Ph.D., and Rutger J. Ploeg, M.D., Ph.D.

N Engl J Med 2009;360:7-19

IL-4 inhibits TGF- ß -induced Foxp3 T cells and, together with TGF-ß, generates IL-9 IL-10 Foxp3 effector T cells

Valerie Dardalhon, Amit Awasthi, Hyoung Kwon, George Galileos, Wenda Gao, Raymond A Sobel, Meike Mitsdoerffer, Terry B Strom, Wassim Elyaman, I-Cheng Ho, Samia Khoury, Mohamed Oukka & Vijay K Kuchroo

Nature Immunology 2008; 9,12. doi:10.1038/ni.1677

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica: http://www.sciencemag.org/cgi/content/abstract/1156995

Catherine Dostert, Virginie Pétrilli, Robin Van Bruggen, Chad Steele, Brooke T. Mossman, Jürg Tschopp

Science 320, 674 (2008); doi:10.1126/science.1156995